Found a great business, location don't interest me - still move forward ?

After a year of search , i found a great business. I live in metro area now and the population is approximately 4 million. The business of interest is in a city with a population of 400k with major international airports 4 hours away, although it has a regional airport.

I know its a personal preference, I wanted to what the searchers did in the past when acquiring a business of interest.